Metabolome profiling across liver lobes and metabolic shifts of the MASLD mice

Genes & Nutrition

Table 3 Assessing the impact of interventions on the variation among liver lobes using linear mixed model

Comparison Groups	Number of variable metabolites and lipids between liver lobes	Number of variable lipids between liver lobes	Number of variable metabolites between liver lobes	Number of variable lipid subclasses between liver lobes
8LFD vs. 8HFD	249	221	28	3
8LFD vs. 8HFHC	308	295	13	16
8HFD vs. 8HFHC	356	312	44	14
16LFD vs. 16HFD	294	265	29	9
16LFD vs. 16HFHC	275	263	12	11
16HFD vs. 16HFHC	244	232	12	10
8LFD vs. 16LFD	92	80	12	4
8HFD vs. 16HFD	163	144	19	5
8HFHC vs. 16HFHC	50	48	2	3

We evaluated the impact of feedings on the variation among liver lobes by calculating the numbers of differential compounds across liver lobes. The numbers indicated the quantity of differential compounds across liver lobes between different groups. Compounds were considered statistically significant if the p-value (FDR correction) < 0.05. Detailed information for each compound is provided in the Supplementary Data 3, 4

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