Table 6 Effect of VIS on serum levels of liver, kidney function parameters, and oxidative/antioxidative shuttle system

Normal control

131^d ± 3.93

68.07^f ± 1.79

28.13^d ± 1.7

0.78^d ± 0.03

164.05^a ± 4.19

5.95^a ± 0.62

0.45^d ± 0.04

VIS control

113.82^f ± 8.65

70.29^f ± 4.61

26.69^d ± 2.2

0.77^d ± 0.01

169.23^a ± 4.08

6.48^a ± 0.38

0.58^d ± 0.08

RA control

226.75^a ± 5.46

159.92^a ± 6.76

57.66^a ± 1.95

1.3^a ± 0.04

23.04^d ± 3.3

0.36^d ± 0.04

13.81^a ± 1.29

MTX treatment

197.55^b ± 2.51

130^b ± 5.89

49.06^b ± 0.55

1.08^b ± 0.01

128.55^b ± 1.07

2.92^b,c ± 0.08

7.58^b ± 0.31

VIS prophylactic treatment

121.86^e ± 1.18

109.91^c ± 6.75

39^c ± 0.74

0.99^b ± 0.01

171.95^a ± 6.15

6.2^a ± 0.27

2.08^d ± 0.17

VIS post-treatment

159.35^c ± 9.73

109.95^c ± 3.9

40.68^c ± 0.93

0.98^b ± 0.01

92.29^c ± 6.41

2.05^c ± 0.52

5.1^c ± 0.16

VIS + MTX Combination treatment

107^f ± 3.52

89.21^d ± 1.14

29.96^d ± 0.63

0.85^c ± 0.01

92.25^c ± 2.36

3.57^b ± 0.24

1.04^d ± 0.03