Table 4 ADMET properties of the VIS and MTX
|  | Molecular Weight (g/mol) | Blood–Brain Barrier (BBB) | %Human Intestinal Absorption (HIA +) | TPSA A2 | Log p | HBA | HBD | N rotatable | AMES toxicity | Carcinogenicity |
|---|---|---|---|---|---|---|---|---|---|---|
Acceptable ranges | ≤ 500 | No | > 80% high < 30% low | ≤ 140 | < 5 | 2.0–20.0 | 0.0–6.0 | ≤ 10 | Nontoxic | Noncarcinogenic |
VIS | 230.219 | No | 99.251 | 52.85 | 2.878 | 4 | 0 | 1 | Nontoxic | Noncarcinogenic |
MTX | 454.447 | No | 20.241 | 210.540 | -1.687 | 13 | 7 | 10 | Toxic | Noncarcinogenic |